Scholar Rock to Present Data from the Phase 1 DRAGON trial at the SITC 37th Annual Meeting
Poster presentation includes Part A safety, efficacy and biomarker data and Part B update
“We are encouraged by the early clinical data from the ongoing DRAGON Phase 1 clinical trial and look forward to sharing these results at SITC, as well as at future medical meetings as more SRK-181 data from both Part A and B become available,” said
SRK-181 is an investigational selective inhibitor of latent TGFβ1 activation and is being developed with the aim of overcoming primary resistance to checkpoint therapy in advanced cancer patients. Combination therapy with selective TGFβ1 blockade may modulate the tumor microenvironment, allowing for immune cell infiltration and potential improvements in the response rate and survival time of cancer patients.
Details of the presentations are as follows:
Title: SRK-181, a latent TGFβ1 inhibitor: safety, efficacy, and biomarker results from the dose escalation portion of a phase I trial (DRAGON trial) in patients with advanced solid tumors
Presentation Type: Poster 780
Location: Poster Hall
The abstract for this presentation is available on SITC’s website: www.sitcancer.org/2022/abstracts/abstract-titles-publications
The presentation will be made available in the Publications & Posters section of Scholar Rock’s website following the conference.
For conference information, visit www.sitcancer.org/2022/program/annual-meeting
SRK-181 is a selective inhibitor of TGFβ1 activation being developed to overcome primary resistance to checkpoint inhibitor therapy, such as anti-PD-(L)1 antibodies, in advanced cancer. TGFβ1 is the predominant TGFβ isoform expressed in many human tumor types. Based on analyses of various human tumors that are resistant to anti-PD-(L)1 therapy, data suggest TGFβ1 is a key contributor to the immunosuppressive tumor microenvironment, excluding and preventing entry of cytotoxic T cells into the tumor, thereby inhibiting anti-tumor immunity.(1)
(1) Martin et al., Sci. Transl. Med. 12:
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