United States securities and exchange commission logo

                           November 21, 2022

       Jay Backstrom
       Chief Executive Officer
       Scholar Rock Holding Corp
       301 Binney Street
       Cambridge, MA 02142

                                                        Re: Scholar Rock
Holding Corp
Statement on Form S-3
                                                            Filed November 14,
                                                            File No. 333-268329

       Dear Jay Backstrom:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Dillon
Hagius at 202-551-7967 with any questions.


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Jesse R. Fishman