June 6, 2019

Nagesh K. Mahanthappa
Chief Executive Officer
Scholar Rock Holding Corporation
620 Memorial Drive, 2nd Floor
Cambridge, MA 02139

       Re: Scholar Rock Holding Corporation
           Registration Statement on Form S-3
           Filed June 3, 2019
           File No. 333-231920

Dear Mr. Mahanthappa:

       This is to advise you that we have not reviewed and will not review your

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Donald Field at 202-551-3680 with any questions.


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